Nowadays digital and analog synthesizers can produce a nearly infinite number of sounds, and many of them sound terrible to most people. If you find yourself more in the Trent Reznor music camp though and love making dystopian, harsh sounds in your music, watch this video. It will teach you how to make a really harsh, dissonance filled lead synth track in Reason 4. Great for glitch, industrial, and other abrasive electronic styles.
Catch the written tutorial here.